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Analysis Software

TotalLab Quant Selected Features

Quant Overview | TotalLab Quant Features | Download Free Trial

Major New Features of Version 11.5 

  • New Electronic license that now works under Vista and Windows 7
  • Ability to load in JPG, PNG, BMP and color images
  • Multiplex analysis
  • All New reports
  • Histogram Window
  • Profile Deconvolution

Other New Features of Version 11.5 

  • All Band Detection parameters (except peak % type)
  • All background methods
  • Made "Normalisation" into QCal sub mode
  • Added Lane Quantity Cal method
  • Removed markers from Image Editor
  • Control centre straight to program
  • Some button updates
  • Invert Image button replaces Colour one
  • 1:1 printing option
  • Quantity Calibration report now includes gel image
  • Can now use raw pixel values in contrast. Helps on some images
  • Lane names data entry from 1D
  • Band and Lane % now reported to 3 decimal places
  • Band Name and PID editable and visible
  • Band Width in mm result in table
  • FWHM (Full Width Half Max) in mm result in table if Gaussian fitted

1D analysis

Lane Creation

  • Automatic or manual lane detection
  • Multi-tier detection
  • Select area of interest
  • Move, resize and bend lanes
  • Smile correcton tool for distorted lanes
  • Specify lane width in pixels
  • Add/Delete lane tools

Background Subtraction

  • 5 automatic methods
  • 3 manual methods

Band Detection

  • Fully automatic band detection
  • 3 adjustable peak parameters
  • 4 band edge detection methods
  • Manual editing of peak and edge detection
  • View multiple lane profiles either stacked or overlaid
  • Band measurements automatically displayed in Measurements Table
  • Automatic updating of tables
  • Choice of 14 data fields to display in easurements Table
  • Export lane profile information

Molecular Size / pI Calibration

  • Library of standards
  • Add new standards
  • Edit existing standards
  • 6 Curve Fitting Methods
  • MW's automatically displayed in Measurements Table

Quantity Calibration

  • 5 Curve Fitting methods
  • Range of calibration units
  • Volumes calculated automatically displayed in Measurements table

Normalization

  • Normalize to a single band
  • Normalize to a group of bands, based on average or collective volume
  • Choice of 10 normalization units

Additional Features

  • Automatic lane report with various customizable options
  • Ruler options to display lane names, numbers and MW's
  • Automatic PDF report generator

Array analysis

Grid Definition

  • Automatic grid detection
  • Grids can be exported to and imported from a file
  • Choice of 3 spot shapes
  • Define spot diameter prior to grid creation
  • Detects grids up to 1,536 spots
  • Standard grid types supplied
  • Create new grid formats
  • Edit existing grid types
  • Resize grids
  • Adjust for skewed images
  • Delete selected grid

Spot Editing

  • Reposition spots
  • Resize spots
  • Make changes to individual spots, groups of spots, entire grid
  • Spot properties dialog
  • Spot label field

Spot Measurement

  • Volumes automatically calculated following grid detection
  • Data displayed in Measurements Table
  • 3 display types in Measurement Table
  • Dynamic updating of tables
  • Choice of 10 fields to display in Measurements Table
  • Show/hide spot numbers
  • Select spots for negative controls
  • Select spots that will not be measured

Background Subtraction

  • 2 fully automatic methods
  • 2 semi automatic methods

Normalization

  • Choice of 10 quantity units
  • Single click operation
  • Normalize to single or group of spots
  • Normalize to spot group average or collective volume

Presence/Absence Flagging

  • Automatic flagging based on estimate of threshold
  • Manual setting of threshold
  • View results in Measurements Table
  • Color overlay of image to view flagging results

Colony/2D Spot

Spot Detection

  • Define circular or rectangular area of interest
  • Easy control slider bars for sensitivity and operator size
  • Initialize sensitivity option
  • Advanced parameter settings for sensitivity, noise, operator size and background
  • Automatic splitting function
  • Total count and spot data automatically displayed in Measurements Table
  • Choice of 8 data fields to display in Measurements Table

Editing

  • Draw, erase, delete or split features
  • Adjustable pen size for drawing or erasing
  • Renumber or delete all features

Background Subtraction:

  • Choice of 2 methods

21CFR Part 11 Module

System Access

  • Windows security model to restrict access
  • User log-on required to start software
  • Three levels of access
  • Password copying disabled

Data Integrity and Security

  • Data stored in Secure Storage Area as human readable xml files
  • Will not analyze or store corrupt data
  • No analysis possible on non 21CFR module data or images already in use
  • Archival of experiment data and history
  • Store multiple versions of experiment
  • Retrieve any version as read-only

Audit Trails

  • Records all user log-on/log-offs, approval signatures, and log-on success/failures
  • Version Control records all global experiment actions
  • Experiment Audit records actions required to repeat experiment (lane creation, band detection, etc.)
  • Includes user name and time/date of action

Electronic Signatures

  • Approval of completed experiments, requiring re-entering password details
  • Analysis reports state of approval, including name, date, time and reason for approval

Validation Documentation

  • Describes map between software and 21 CFR Part 11 rule to validate software
  • Standard audit response document

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